Ozempic: a weight loss solution?

E.C | Pharmacist

7/24/20232 min read

Understanding the Mechanism:

Ozempic, generically known as semaglutide, is a GLP-1 receptor agonist. GLP-1 (Glucagon-Like Peptide-1) is a hormone produced in the intestines that plays a crucial role in regulating blood sugar levels and appetite. When Ozempic is introduced into the body, it mimics the action of GLP-1 by binding to its receptors. This triggers a cascade of effects that are beneficial for weight loss.

Evidence-Based Effectiveness:

Numerous clinical trials have explored the weight loss potential of Ozempic. One notable study is the SUSTAIN-6 trial, where participants with type 2 diabetes were administered Ozempic. The results were groundbreaking; participants not only experienced improved blood sugar control but also an average weight loss of around 4.7 kg (10.4 lbs) over the course of one year [1].

Furthermore, the STEP trials, which included participants without diabetes, demonstrated significant weight loss. In the STEP 1 trial, participants receiving Ozempic experienced an average weight loss of approximately 14.9% of their initial body weight [2]. This emphasises that Ozempic's weight loss effects extend beyond diabetic populations.

The Science Behind Ozempic:

Ozempic's effectiveness in weight loss can be attributed to several factors:

  1. Appetite Suppression: Ozempic slows down stomach emptying and reduces the feeling of hunger. This leads to decreased food intake and ultimately aids in weight loss.

  2. Brain Signaling: GLP-1 receptors are present in the brain, influencing the reward centre and reducing cravings for high-calorie foods.

  3. Insulin Sensitivity: Improved insulin sensitivity helps prevent excess glucose storage as fat and promotes energy utilisation.


While Ozempic has shown impressive weight loss results, it's important to remember that individual responses can vary. Some users may experience more significant weight loss, while others may see milder effects. Additionally, Ozempic should not be considered a standalone solution for weight loss. A balanced diet and regular physical activity remain crucial components of a healthy lifestyle. Moreover, as with any medication, consulting with a healthcare professional before use is essential to ensure its appropriateness for individual health goals.


  1. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. (n.d.). https://www.nejm.org/doi/full/10.1056/NEJMoa1607141

  2. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. (n.d.). https://www.nejm.org/doi/full/10.1056/NEJMoa1607141

Recently, the popularity of Ozempic has been spreading massively, not only for its ability to control blood sugar levels but also for its potential to facilitate weight loss. But does it really work and is it that effective as largely as media is making it? This article dives into the science and evidence behind Ozempic's weight loss effects.